日本，肾癌肺转索坦有效期间出现脑转1例

タイトル:         肺転移に対するスニチニブの奏功期間中に脳転移が出現した腎細胞癌の1例
その他のタイトル:         Brain Metastasis which Appeared during Complete Response of Lung Metastatic Lesion by Sunitinib Treatment in a Patient with Renal Cell Carcinoma
著者:         森澤, 洋介
百瀬, 均
豊島, 優多
高田, 聡
藤本, 健
大山, 信雄
著者名の別形:         Morizawa, Yosuke
Momose, Hitoshi
Toyoshima, Yuta
Takada, Satoshi
Fujimoto, Ken
Oyama, Nobuo
キーワード:         Brain metastasis
Renal cell carcinoma
Sunitinib
発行日:         Dec-2013
出版者:         泌尿器科紀要刊行会
誌名:         泌尿器科紀要
巻:         59
号:         12
開始ページ:         791
終了ページ:         793
抄録:         A 59-year-old man underwent radical nephrectomy for left renal cell carcinoma with multiple lung metastases (cT3bN0M1) in May 2010. Pathological diagnosis was clear cell carcinoma, G2 and pT3b. After sunitinib treatment for 7 months computed tomography (CT) revealed complete response of lung lesions and the treatment was continued. After 10 months, the patient complained of right hemiplegia. Brain magnetic resonance imaging (MRI) revealed a 3 cm tumor in his frontal lobe of cerebrum. He underwent surgical resection of the tumor and pathological diagnosis was metastatic renal cell carcinoma. He has been well without local recurrence or distant metastasis for 18 months.

腺泡状软组织肉瘤的病人就有很多靶向药有效期间发生脑转的病例。我们的病友中就有吃索坦肺部有效，但发生了脑转。

我有认识的病友，也是服索坦对肺转控制住了最近发现脑转！不知各位有什么好的建议？

提示病友，即使在靶向药有效期间，也不要忽视对脑部的监查，早期发现处理容易，可手术、可伽马刀、可X刀损害较轻，发现晚了可能只有全脑放，损害相当大。

bhq 发表于 2014-6-13 09:48
提示病友，即使在靶向药有效期间，也不要忽视对脑部的监查，早期发现处理容易，可手术、可伽马刀、可X刀损 ...

对！我家是典型的反面教材！{:soso_e115:}