看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
+ o! l5 x& w% P ~& M9 T6 ~3 K3 a- o9 t9 i, X
@2 u* |9 ]3 A
Currently available feasibility data for possible combination strategies. , s) C& T2 w" i$ W( G2 y: l; m
————————————————————————————————
8 Q6 r" Z- T r' |6 }Combination Feasibility according to preliminary data
z# _" t4 D' Z. `: q2 E" z——————————————————————————————————" b% {. E6 c! e' |1 W9 p7 c0 J
Bevacizumab + sorafenib Yes, reduced dose : ]& A# D4 o: ]% Z& x, A, Y( a z
Bevacizumab + sunitinib† No 0 p! o% f; [7 Z6 u
Bevacizumab + temsirolimus Yes # I0 ^5 O9 O: d: T, ]0 U
Bevacizumab + everolimus Yes - @- p- H- |) u; o
Sorafenib + sunitinib ? + F. l* }/ s& U
Sorafenib + temsirolimus Yes, reduced dose
2 I$ q: {8 R. F3 g# j* s `. ESorafenib + everolimus Yes, reduced dose
9 h3 Z2 Y* c0 A! KSunitinib + temsirolimus† No
3 Z2 E% P) n2 ^Sunitinib + everolimus ?
) \( l9 k6 c" M1 ]Temsirolimus + everolimus ?
$ h2 O& }0 n3 `. G————————————————————
7 q3 l. K U1 c: P4 b- K {1 |3 t†Led to US FDA warning.: ]& k1 i2 [: f. Y" \4 n3 K
?: As yet unattempted combination.$ j1 h, e4 q+ ]0 W" _/ \6 b
|