发给老马备查:, a; ]' F; M% q: F
滴水察海(69304838) 15:23:23
, G& n" Z5 `+ o: v4 y4 A, m老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱+ W9 h9 O: T' c) R+ f0 e6 r2 v" B
吉非替尼和S-1连用的依据( g' N' w [+ G- w; o& U
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
* u9 m* I0 \2 C8 u3 x4 c是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
+ L$ }8 k1 b$ t% }: j, F这样是不是推理出,耐药后,可以用S-1和培美了?
- s, U; C' T, v) ?$ d: ~结论:
& B! L4 \$ W. C- C/ q& R1 U0 m如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |