发给老马备查:4 K: [6 {0 [. Q# C J" O! h- r6 u
滴水察海(69304838) 15:23:23
1 p& z4 R- W8 @0 C* K老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱, V- l8 a0 W8 O* M
吉非替尼和S-1连用的依据( y6 o. T" ?6 v$ m/ F2 ^) T, w
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' d# I* o% ]# O* t% ]: S1 X) p是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
* ~/ {- H% W$ X% P: K这样是不是推理出,耐药后,可以用S-1和培美了?
7 E4 h9 t, h* M/ T, ~结论:
2 b4 }! y3 X1 b# ?4 u' u2 Z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |