发给老马备查:
( ], j7 P- D% y- s% c9 w滴水察海(69304838) 15:23:23
) s6 G- |" A" t0 V% g4 v老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; \/ F8 o7 y8 D吉非替尼和S-1连用的依据# W! [" c. b) _$ z+ J, O7 {
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
9 p# i, |- B& h* J, k ]是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达2 Z1 h0 ]2 V# c, Z
这样是不是推理出,耐药后,可以用S-1和培美了?& ]+ e+ S' o$ S' w, J O" N
结论:8 i! E$ c' ~1 W6 X4 o
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |