发给老马备查:
4 e8 u7 y3 `/ L) u滴水察海(69304838) 15:23:23
+ `( X: e; k' n/ d" J老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
0 N$ k7 a3 s/ u0 p. M7 Q吉非替尼和S-1连用的依据
" `' z, q# x- ?7 qGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
# K4 {2 v" t6 D. g* P# g6 e是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 z0 [( N v3 i9 h
这样是不是推理出,耐药后,可以用S-1和培美了?6 Y# l L& w, D C5 m
结论:
4 \' w. }7 U" n! s* X- t( R, A如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |