发给老马备查:' k4 ^/ A# K, `1 c6 `+ w" r
滴水察海(69304838) 15:23:23
. @- q. U4 b" U老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
. |' B$ u, Q; g |吉非替尼和S-1连用的依据' m; O6 |& E$ J8 {7 `9 b; S; G
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
( h0 K! t( ^( X0 w- v- @5 u( b是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达- d2 _5 C$ r2 q7 B6 V
这样是不是推理出,耐药后,可以用S-1和培美了?
) j+ S0 n% x1 C4 B" q结论:0 F+ |0 E$ c$ Q- W$ X- `9 @
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |